๐—ฅ๐—œ๐—ฃ ๐—ฅ๐—ฒ๐˜ƒ. ๐—๐—ฒ๐˜€๐˜€๐—ฒ ๐—๐—ฎ๐—ฐ๐—ธ๐˜€๐—ผ๐—ป.

RIP

He'd been ill for several years with progressive supranuclear palsy. Not a good way to go.

You may have heard about Progressive supranuclear palsy (PSP) in the news lately, as a result of Reverand Jesse Jacksonโ€™s recent announcement about having the disease. You may also be aware that in 2017, Rev. Jackson announced that he was diagnosed with Parkinsonโ€™s disease (PD). It turns out that like in Rev. Jacksonโ€™s case, PD and PSP are often confused with each other, especially early in the disease course. The diagnosis may then be revised as new symptoms develop.

PSP vs. PD

While there are some similarities between Parkinsonโ€™s disease (PD) and PSP, they are distinct conditions with distinct symptoms, pathologies and rates of decline. PSP is a much less common diagnosis than PD. Both diseases can start with slowness of movement and stiffness. However, people with PSP tend not to have the classic rest tremor that can be very characteristic of PD and people with PSP often develop specific eye movement abnormalities that people with PD do not have. In addition, people with PSP tend not to respond to Parkinsonโ€™s medications as well as people with PD.

One of the hallmarks of PSP is early, unprovoked falls. People with PSP often retropulse or fall backward without the ability to catch themselves. Poor balance and falling in PD on the other hand, typically occurs in more advanced stages.

Both diseases show neurodegeneration, or nerve cell death, in specific brain cells involved in motor control. However, whereas the protein alpha-synuclein tends to accumulate in the brains of people with PD, the protein tau is present in the brains of people with PSP.

Unfortunately, in addition to the fact that PSP typically shows a more limited response to medications, it also tends to progress more quickly.
 
Back
Top