Republicans count enough competitive races to challenge Democrats for control of the Senate in the 2014 elections.
Republicans need a net gain of six seats to capture control from Democrats, who effectively hold a 55-45 advantage now.
But Democrats will be defending 21 of 35 seats to be decided in November, and President Barack Obama is looking like a major drag for them.
Midterm elections are often tough for a president's party in any event.
"History is with us, geography is with us and the president's signature legislative achievement is the most unpopular" law of his tenure, Rob Collins, executive director of the National Republican Senatorial Committee, said of Obama and his health care overhaul.
Republicans inside and outside the Senate speak confidently about snatching open seats in West Virginia and South Dakota.
They like their chances against Democratic incumbents in Republican-leaning Arkansas, Louisiana and Alaska and remain upbeat about Montana even if Democratic Gov. Steve Bullock names Lt. Gov. John Walsh to succeed Sen. Max Baucus, Obama's choice for U.S. ambassador to China.
Guy Cecil, executive director of the Democratic Senatorial Campaign Committee, argued that the presence of tea partyers in primaries is forcing all Republican candidates to race to the right. The result is nominees unacceptable in the general election, he said.
Republicans insist that establishment candidates will eventually prevail and the internal fights won't matter as Democrats struggle with the most contentious issue of the year — Obama's health care law — and the political damage from its many problems.
Democrats don't dispute that the troubled rollout of the health care website has hurt them.
"There's no doubt Republicans are a little more gleeful," said John Anzalone, a Democratic pollster and adviser to North Carolina Democratic Sen. Kay Hagan, who is seeking a second term. "Who can say with a straight face that this has not been bad for Democrats?"
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