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Cancer and inflammation are closely linked, as chronic inflammation can increase the risk of developing various types of cancer. Inflammation may promote tumor growth and spread by creating an environment that supports cancer cell proliferation and survival.
cancercenter.com
Wikipedia
The Relationship Between Cancer and Inflammation
Understanding Inflammation
Inflammation is a natural response of the immune system to injury or infection. It involves the release of white blood cells and chemicals to help heal damaged tissues. However, when inflammation becomes chronic, it can lead to various health issues, including cancer.
Inflammation as a Cancer Risk Factor
Chronic inflammation is linked to the development and progression of cancer. It is estimated that 15% to 20% of cancer-related deaths are associated with inflammation. This prolonged inflammatory state can damage healthy cells and create an environment conducive to tumor growth.
Mechanisms of Inflammation in Cancer
- Tumor Promotion: Inflammatory processes can stimulate the growth of blood vessels that supply tumors with nutrients and oxygen.
- Genetic Damage: Chronic inflammation may lead to mutations in DNA, contributing to cancer development.
- Immune Evasion: Tumors can exploit the inflammatory environment to evade immune detection, allowing them to grow and spread.
Therapeutic Opportunities
Research is ongoing to explore anti-inflammatory therapies as potential cancer treatments. Some studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs), like aspirin, may reduce the risk of certain cancers, particularly colorectal cancer.
Conclusion
The interplay between cancer and inflammation is complex. While inflammation is essential for healing, its chronic form can significantly increase cancer risk. Understanding this relationship opens avenues for new treatment strategies targeting inflammation in cancer therapy.
Wikipedia
BioMed Central