A cancer patient has made a full recovery after being injected with billions of his own immune cells in the first case of its kind, doctors have disclosed.
The 52-year-old, who was suffering from advanced skin cancer, was free from tumours within eight weeks of undergoing the procedure.
Doctor's use patient's own immune cells to beat cancer
The case could be a landmark in cancer treatment
After two years he is still free from the disease which had spread to his lymph nodes and one of his lungs.
Doctors took cells from the man's own defence system that were found to attack the cancer cells best, cloned them and injected back into his body, in a process known as "immunotherapy". After two years he is still free from the disease which had spread to his lymph nodes and one of his lungs.
Experts said that the case could mark a landmark in the treatment of cancer.
It raises hopes of a possible new way of fighting the disease, which claims 150,000 lives in Britain every year.
Ed Yong, health information manager at Cancer Research UK, said: "It's very exciting to see a cancer patient being successfully treated using immune cells cloned from his own body. While it's always good news when anyone with cancer gets the all clear, this treatment will need to be tested in large clinical trials to work out how widely it could be used."
However, the treatment could prove extremely expensive and scientists say that more research is needed to prove its effectiveness.
Genetically altered white blood cells have been used before to treat cancer patients but this is the first study to show that simply growing vast numbers of the few immune cells in the body to attack a cancer can be safe and effective.
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Normally there are too few of the cells in a patient's body to effectively fight cancer.
Dr Cassian Yee, who led the team at the Fred Hutchinson Cancer Research Centre in Seattle, said: "For this patient we were successful, but we would need to confirm the effectiveness of therapy in a larger study."
The work raises hopes that this approach could not only offer a more effective treatment for skin cancer, or melanoma, which kills around 2,000 people in Britain alone, but be applied to other cancers too.
The patient was one of nine with metastatic melanoma, that is skin cancer that has spread, who were being treated in a recently completed clinical trial to test bigger and bigger doses of their own white blood cells.
Larger, more elaborate, trials are now under way.
Almost 9,000 new cases of melanoma, the most serious form of skin cancer, are diagnosed every year in Britain, and nearly 2,000 patients die from the disease.
Prof Peter Johnson, Cancer Research UK's chief clinician, said: "This is another interesting demonstration of the huge power of the immune system to fight some types of cancer.
"Although the technique is complex and difficult to use for all but a few patients, the principle that someone's own immune cells can be expanded and made to work in this way is very encouraging for the work that Cancer Research UK and others are carrying out."
Immunotherapy, in which a patients own immune cells are used to treat cancer, is a growing area of research that aims to develop less-toxic treatments than standard chemotherapy and radiation.
Because cancer occurs when the body's own cells grow out of control, the immune system only responds weakly.
The ability of the body's own defences to tackle cancer in this case is all the more remarkable because most deadly feature of the disease is its ability to colonise other parts of the body, when it becomes much more difficult to treat.
A dramatic example of immunotherapy was reported two years ago by one pioneer of the field, Dr Steven Rosenberg of the US National Cancer Institute, who eradicated cancer from two dying men using genetically modified versions of their own cells.
Both Mark Origer and "Thomas M" were suffering from advanced melanoma but the hope is that such methods could be customised to attack other common cancers, notably breast, colon and lung.
Dr Rosenberg told The Daily Telegraph the new work is an "interesting study that helps to confirm the effectiveness of cell transfer immunotherapy for treating cancer patients. We have now treated 93 patients with metastatic melanoma using their own anti-tumour cells with response rates up to 72 per cent. Mark Origer remains disease free now over three years after treatment."
Information appearing on telegraph.co.uk is the copyright of Telegraph Media Group Limited and must not be reproduced in any medium without licence. For the full copyright statement see Copyright
http://www.telegraph.co.uk/earth/main.jhtml?xml=/earth/2008/06/18/scicanc118.xml
The 52-year-old, who was suffering from advanced skin cancer, was free from tumours within eight weeks of undergoing the procedure.
Doctor's use patient's own immune cells to beat cancer
The case could be a landmark in cancer treatment
After two years he is still free from the disease which had spread to his lymph nodes and one of his lungs.
Doctors took cells from the man's own defence system that were found to attack the cancer cells best, cloned them and injected back into his body, in a process known as "immunotherapy". After two years he is still free from the disease which had spread to his lymph nodes and one of his lungs.
Experts said that the case could mark a landmark in the treatment of cancer.
It raises hopes of a possible new way of fighting the disease, which claims 150,000 lives in Britain every year.
Ed Yong, health information manager at Cancer Research UK, said: "It's very exciting to see a cancer patient being successfully treated using immune cells cloned from his own body. While it's always good news when anyone with cancer gets the all clear, this treatment will need to be tested in large clinical trials to work out how widely it could be used."
However, the treatment could prove extremely expensive and scientists say that more research is needed to prove its effectiveness.
Genetically altered white blood cells have been used before to treat cancer patients but this is the first study to show that simply growing vast numbers of the few immune cells in the body to attack a cancer can be safe and effective.
advertisement
Normally there are too few of the cells in a patient's body to effectively fight cancer.
Dr Cassian Yee, who led the team at the Fred Hutchinson Cancer Research Centre in Seattle, said: "For this patient we were successful, but we would need to confirm the effectiveness of therapy in a larger study."
The work raises hopes that this approach could not only offer a more effective treatment for skin cancer, or melanoma, which kills around 2,000 people in Britain alone, but be applied to other cancers too.
The patient was one of nine with metastatic melanoma, that is skin cancer that has spread, who were being treated in a recently completed clinical trial to test bigger and bigger doses of their own white blood cells.
Larger, more elaborate, trials are now under way.
Almost 9,000 new cases of melanoma, the most serious form of skin cancer, are diagnosed every year in Britain, and nearly 2,000 patients die from the disease.
Prof Peter Johnson, Cancer Research UK's chief clinician, said: "This is another interesting demonstration of the huge power of the immune system to fight some types of cancer.
"Although the technique is complex and difficult to use for all but a few patients, the principle that someone's own immune cells can be expanded and made to work in this way is very encouraging for the work that Cancer Research UK and others are carrying out."
Immunotherapy, in which a patients own immune cells are used to treat cancer, is a growing area of research that aims to develop less-toxic treatments than standard chemotherapy and radiation.
Because cancer occurs when the body's own cells grow out of control, the immune system only responds weakly.
The ability of the body's own defences to tackle cancer in this case is all the more remarkable because most deadly feature of the disease is its ability to colonise other parts of the body, when it becomes much more difficult to treat.
A dramatic example of immunotherapy was reported two years ago by one pioneer of the field, Dr Steven Rosenberg of the US National Cancer Institute, who eradicated cancer from two dying men using genetically modified versions of their own cells.
Both Mark Origer and "Thomas M" were suffering from advanced melanoma but the hope is that such methods could be customised to attack other common cancers, notably breast, colon and lung.
Dr Rosenberg told The Daily Telegraph the new work is an "interesting study that helps to confirm the effectiveness of cell transfer immunotherapy for treating cancer patients. We have now treated 93 patients with metastatic melanoma using their own anti-tumour cells with response rates up to 72 per cent. Mark Origer remains disease free now over three years after treatment."
Information appearing on telegraph.co.uk is the copyright of Telegraph Media Group Limited and must not be reproduced in any medium without licence. For the full copyright statement see Copyright
http://www.telegraph.co.uk/earth/main.jhtml?xml=/earth/2008/06/18/scicanc118.xml
