http://en.wikipedia.org/wiki/Conception_(biology)
Fertilisation (also known as conception, fecundation and syngamy), is the fusion of gametes to produce a new organism. In animals, the process involves a sperm fusing with an ovum, which eventually leads to the development of an embryo. Depending on the animal species, the process can occur within the body of the female in internal fertilisation, or outside in the case of external fertilisation
The entire process of development of new individuals is called procreation, the act of species reproduction.
Usually mammals rely on internal fertilisation through copulation. After a male ejaculates, a large number of sperm cells move to the upper vagina (via contractions from the vagina) through the cervix and across the length of the uterus toward the ovum. The capacitated spermatozoon and the oocyte meet and interact in the ampulla of the fallopian tube. It is probable that chemotaxis is involved in directing the sperm to the egg, but the mechanism has yet to be worked out. However, demonstration of formyl peptide receptors (60.000 receptor/cell; higher binding capacity in the tail region) in the surface membrane of human sperms strongly supports, that - besides specific chemoattractant substances i.e. resact - professional chemoattractant ligands like formyl Met-Leu-Phe (fMLF) have also the ability to induce migration of sperm.[6]
The sperm binds to the zona pellucida of the egg. In contrast to sea urchins, the sperm binds to the egg before the acrosmal reaction. The zona pellucida is a thick layer of extracellular matrix that surrounds the egg and is similar to the role of the vitelline membrane in sea urchins. A glycoprotein in the zona pellucida, ZP3 was discovered to be responsible for egg/sperm adhesion in mice. The receptor galactosyltransferase (GalT) binds to the N-acetylglucosamine residues on the ZP3 and is important for binding to sperm and activating the acrosome reaction. ZP3 is sufficient for sperm/egg binding but not necessary. There are two additional sperm receptors: a 250kD protein that binds to an oviduct secreted protein and SED1 which binds independently to the zona. After the acrosome reaction, it is believed that the sperm remains bound to the zona pellucida through exposed ZP2 receptors. These receptors are unknown in mice but have been identified in guinea pigs.
In mammals, binding of the spermatozoon to the GalT initiates the acrosome reaction. This process releases the enzyme hyaluronidase, which digests the matrix of hyaluronic acid in the vestments surrounding the oocyte. Fusion between the sperm and oocyte plasma membranes follows, allowing the entry of the sperm nucleus, centriole and flagellum, but not the mitochondria, into the oocyte. The fusion is likely mediated by the protein CD9 in mice (the binding homolog). The egg "activates" once it fuses with a single sperm cell, i.e., its cell membrane changes to preventing fusion with other sperm.
This process ultimately leads to the formation of a diploid cell called a zygote. The zygote begins to divide and form a blastocyst and when it reaches the uterus, it performs implantation in the endometrium.
The term conception commonly refers to fertilisation, the successful fusion of gametes to form a new organism.