Libya/rise of ISIS with fracturing of Iraq/ - diminution of US alliances make everybody nervous and add to increased instability.
Hot war in Syria with a weakened Assad gives way to Russia and a hot war with a strengthened Assad ,and Iran.
Saudi Arabia gives up on Lebanon, empowering Hezbolah, making everybody more nervous.
Iran fomenting the Houthi in Yemen, and SA bombing the crap out of everything that moves
because King Salman hasn't figured out how to use the SA armed forces
Turkey nervous about the PKK, and lobbing in shells to our allies (Syrian Kurds)..
Iranian expansionism runs wild and unchecked.. this off the top of my head at 6AM.
Obama hiding under the Middle East desk