I don't think our lives are about anything. We're an accident; therefore, life is meaningless.
An accident? Sure, the distribution of life in the universe is subject to some randomness, but this is a universe in which life was possible. Was life not, in some way, fated to be? Should we be disappointing that the method of deciding where it would be just happened to involve some dice rolls rather than being fully deterministic? Really, randomness is just a method of carrying out deterministic rules.
And again, what do you mean by meaningless? Certainly, under this system there's not a guy up there intending everything in your life for you. But really, I've always found it odd that that was ever considered a comforting notion anyway. Wouldn't you rather be in control of your life? I honestly think it's a good thing that there is no God; I think the universe would be much more dreary with one. Sure, we do not have fate, so if, for instance, a tragedy happens we cannot say "Oh, it is all part of a great plan." But really, again, why on Earth should that be a comforting notion? You are really OK with God killing your relative in an accident because of some great plan? Like a totalitarian dictator, except you're juts going to trust him? Thanks, but no thanks, God! I'd rather they be alive!
On one hand, the religious want fate, to give them meaning, and on the other, they want free will. They want to have their cake and eat it to. Really, they want to feel like everything they have no control over in life is fate, and that all of their accomplishments are freely willed, so they can take responsibility for them (their failings are, I assume, the product of Satan, which gets them off in that instance). But the implications of their systems are not really comforting if looked at with any degree of rationality, and in any case, it's little more than a delusional attempt to feel like they have some sort of control over everything in the universe.
Perhaps the universe is not constructed based on that which we most value in ourselves, intelligence, and is merely the product of some other mechanism. Should that really surprise us? Where do we get off in demanding that nature be subjugated to us? That the universe is meaningless somehow just because it doesn't operate like we operate? And why should we be so happy being slaves to some master? Shouldn't we, in fact, be glad to be our own masters, free to forge our own path, and, as far as we can see, the most powerful thing out there? Is there something wrong with being on top, with slavery being such a preferable alternative state of being?