What makes it a good question? Honestly asking because I don't really see the difference. Is it because it "feels" like there must be som "organizing principle"? I understand a lot of people feel that there must be, but without any real evidence that there is.
There are no mysteries or unanswered questions that would lead me to believe there is the remotest possibility of a pink leprechaun in my garage.
The mystery of creation, the mystery of the fine tuning of the universe, the unknown reason for why there are mathematical laws and rational organization might have scientific answers, but they might also point to an ultimate truth or higher organizing principle underlying reality that our primate brains cannot access, percieve, or correctly interpret. That really is the origin of religion, after all.