Well there are at least five instances of Trump attempting to thwart or block the investigations into his administration.
I'm so glad you asked.
Trying to protect Flynn by cajoling Comey into dropping the investigation into his lies and misdealings. On Feb. 14, Trump directed several other officials to leave the Oval Office so he could speak privately with Comey. He then told Comey to “let this go,” referring to the investigation of Michael Flynn, who had resigned the previous day as Trump’s national security adviser.
During a dinner at the White House on Jan. 27, 2017, Trump asked for a pledge of “loyalty” from James Comey, then the F.B.I. director, who was overseeing the investigation of the Trump campaign.
In March and April, Trump told Comey in phone calls that he wanted Comey to lift the ”cloud” of the investigation.
The firing of Comey himself, which Trump admitted, several times, that that action was taken to end the FBI investigation into his administration.
He ordered top White House lawyers to stop Attorney General Jeff Sessions from recusing himself from the Russia investigation. Trump had expected his top law enforcement official to protect him from the investigation. The fact that Trump attempted to influence the way the Justice Department operates adds more evidence showing the president was attempting to obstruct justice.
In March 2017, Trump asked the director of national intelligence, Dan Coats, and the director of the National Security Agency, Mike Rogers, to deny publicly the existence of any evidence of collusion between the Trump campaign and Russia. The conversation was recorded in a memo.
Trump was involved in an effort to cover up the motive for his son Donald Trump Jr.'s arranged meeting with a Kremlin-connected Russian lawyer during the campaign. The president helped draft a misleading statement about the June 2016 meeting at Trump Tower, which was attended by Trump Jr. and other campaign team members.
On May 17, shortly after hearing that the Justice Department had appointed Mueller to take over the Russia investigation, Trump berated Jeff Sessions, the attorney general. The appointment had caused the administration again to lose control over the investigation, and Trump accused Sessions of “disloyalty.”
In June, Trump explored several options to retake control. At one point, he ordered the firing of Mueller, before the White House counsel resisted.
On July 26, in a tweet, Trump called for the firing of Andrew McCabe, the F.B.I.’s deputy director, a potential corroborating witness for Comey’s conversations with Trump. The tweet was part of Trump’s efforts, discussed with White House aides, to discredit F.B.I. officials.
Trump repeatedly made untruthful statements about American intelligence agencies’ conclusions regarding Russia’s role in the 2016 election.
Whether Mueller decides to charge them seperately or lump them all under one umbrella as conspiracy to obstruct justice is up to him as the prosecutor.
I tend to think that he will list them separately as was done in Nixon's case of obstruction.
A list has more impact and demonstrates at the outset a "pattern of intent to obstruct justice".
