1) a. What caused the Big Bang to happen? How exactly does matter and energy spring into existence from nothing?
1) b. Why were the physical and mathematical properties which dropped out of the Big Bang so finely tuned for the creation of complex matter and molecules?
2) a. What is consciousness, and how exactly does it emerge from biochemistry?
2) b. How do electrochemical potentials from our sensory organs result in a rich, subjective mental experience of the physical world?
3) a. How did biology emerge from chemistry, how exactly does matter and energy go from non-being to being?
3) b. Why was there only one genesis of life on Earth around 4 billion years ago (available evidence indicating that all life that ever existed here shares a common genetic origin)? Why is there no evidence of multiple genesis's of different genetic trees of life?
Backdrop:
Real scientists love mysteries and unanswered questions.
Ideological partisans seek to either invoke miraculous intervention, or to sweep inconvenient uncertainties under the rug.