maybe there are other sub atomics that make atom different ? is that any crazier than some DNA replacement ?
if you get bored you should look into it, start with chi
Any discussion about extraterrestrial life is way out in left field, as is the idea to think about the possibility on non-DNA based life.
The reason we aren't going to find anymore naturally occurring elements is because we have have an entire cosmos telling us we got the periodic table right.
200 years of experimental observation on Earth as well as emission spectra of stars, planets, nebula, interstellar gas reveals that we have the naturally-occurring elements of the periodic table dialed in.
It is reasonable to assume we may find additional exotic subatomic particles, aka dark matter. Maybe something even more fundamental than quarks and leptons.
If so, that might effect our understanding of particle physics, but it will not change the chemistry of naturally occurring elements of the periodic table.
DNA is different.
We do not have an entire cosmos telling us about DNA.
We have only ever seen DNA once - on earth.
Not only that, but based on available data, the appearance of DNA on Earth was a unique event - it only happened once, approximately 3.8 billion years ago. All life today is the genetic legacy of those first single celled archae and cyanobacteria. There were not multiple cases of multiple lines of life emerging through Earth history. All genetic information goes back to the first primitive cells.
That is why we might have to prepare ourselves to look for life that is radically different from our genetic heritage.