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Understanding the immunological consequences of mass vaccination during a pandemic of a virus causing acute self-limiting infection (e.g., SARS-CoV-2) is essential. The advent of Omicron signaled the irrevocable loss of the opportunity for the population to develop herd immunity and instead turned mass vaccination into an unprecedented and life-threatening "gain-of-function" experiment with the global population as guinea pigs. Just as Omicron came like a thief in the night, so too will Hi-Vi-Cron surprise society.
Predicting complex biological dynamics requires a rigorous scientific analysis of the fundamental causes of these dynamics and their alignment with forthcoming data and observations, rather than extrapolation from ad hoc data or previous observations. Regarding the ongoing immune escape pandemic, the dominant biological patterns are governed by the evolving dynamics of the virus, molded and remolded by the population-level immune response imprinted by mass vaccination. As these viral evolutionary dynamics were initiated in the wrong direction (the immune response should ideally adjust to the virus, not the other way around!), Nature is now compelled to eliminate all incorrect immune adaptations from the population. This scenario will, however, leave many vaccinated individuals (i.e., those who were vaccinated in ways that made them exclusively reliant on this mistaken immune imprinting) entirely unprotected. I cannot imagine how this would not lead to significantly increased mortality rates before protective herd immunity can be achieved. However, this may only transpire once the rate of excess deaths in vaccinees due to immune suppression or immune-related pathology indirectly resulting from mass vaccination has further increased. (
https://www.voiceforscienceandsolid...ariants-in-highly-c-xx-vaccinated-populations).
The scenario depicted above represents the only means through which nature can transform the ongoing herd immune selection pressure (on viral virulence) exerted by highly COVID-19 vaccinated populations into a state of optimal, sterilizing herd immunity (primarily conferred by the unvaccinated).
The rise in hospitalization and mortality rates could rapidly strain healthcare and funeral service systems in highly COVID-19 vaccinated countries. I therefore urge all healthy unvaccinated individuals to be prepared to assist in such scenarios, whenever and wherever they may arise.*